Cleveland Clinic Neurological Institute and Baszucki Group Team Up to Advance Landmark Brain Study with Metabolic Health Markers
The collaboration seeks to study gut-brain connections in neurological disorders
Although neurological disorders affect one in six people worldwide, a critical knowledge gap remains. Researchers and clinicians have been unable to identify the factors that determine why some individuals are susceptible to these diseases while others remain unaffected.
Principal Investigators Andre Machado MD, PhD, Chairman of the Neurological Institute and the Charles and Christine Carroll Family Endowed Chair in Functional Neurosurgery at the Cleveland Clinic and Imad Najm MD, Director of Cleveland Clinic's Epilepsy Center aim to close this gap by enrolling up to tens of thousands of healthy participants, and tracking biomarkers throughout the body over two decades. By leveraging large-scale, multi-year data, this study will dramatically enhance the potential for identifying and establishing warnings for the earliest signs of brain disorders.
“This study will generate monumental data, enabling us to uncover previously hidden ‘disease fingerprints’,” said Dr. Machado. “What makes this research unique is that it includes assessments never explored before. These novel insights could pave the way for better diagnostics and preventive treatments in the future.”
“By including these additional assessments, the Brain Study is taking a critical step towards understanding the brain within the context of the whole body,” said Jan Ellison Baszucki, co-founder and president of Baszucki Group. “This broad, holistic approach to data gathering is key, as it maximizes the possibility of revealing the underlying factors that contribute to neurological dysfunction and uncovering potential treatment options.”
At this time, the first-of-kind longitudinal study has enrolled more than 4,300 adult volunteers with no known neurological disease to undergo regular comprehensive assessments designed to detect biomarkers and causes of neurological disorders before symptoms manifest. Enrollees have come from nearly every state in the U.S. and have shown tremendous excitement to participate in this research.
To learn more about the study or enroll, visit the study site.
About Baszucki Group
Launched in 2021 by Roblox founder and Chief Executive Officer David Baszucki and best-selling author Jan Ellison Baszucki, Baszucki Group leverages private giving, impact investing, advocacy, storytelling and community building to drive foundational change. A primary objective of Baszucki Group is to transform mental health outcomes by supporting initiatives at the intersection of metabolism, psychiatry, and neuroscience. To learn more about metabolic approaches to mental disorders and brain health, including ketogenic therapy, visit Metabolic Mind, a nonprofit initiative of Baszucki Group.
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