Variational AI Releases Enki 4: Major Update to Foundation Model for Small-Molecule Drug Discovery
Variational AI introduces Enki™ 4: an improved algorithm and architecture designed to scale, expanding the pre-trained target coverage from 592 to 760 and now applicable to proximity-based therapeutics and novel payloads for antibody drug conjugates
“Enki 4 is a massive step forward for our platform,” said Ali Saberali, Co-Founder & Head of Platform at Variational AI. “We’ve re-architected Enki and improved the underlying algorithms to expand target and modality coverage, while operating faster to deliver even better performance for our partners.”
Enki 4 now supports the rapid generation of novel, potent, selective, and synthesizable lead-like structures pre-trained on 760 drug targets, a 28% increase over the previous Enki version’s 592 targets, with more to be released soon. The update delivers enhanced performance across more than 12 target classes, including: GPCRs, kinases, ion channels, proteases, oxidoreductases, hydrolases, and others.
“This Enki release continues our process of continuous model innovation” added Handol Kim, Co-Founder & CEO. “Enki 4 enables our biotech partners to start with novel leads they would not have discovered using traditional methods. Our goal is to eliminate hit ID and hit-to-lead, generating molecules ready to go directly into lead optimization.”
For more information about Enki 4 and to access the full list of 760 targets, visit variational.ai/enki or contact bd@variational.ai.
About Variational AI
Variational AI is a generative AI drug discovery company based in Vancouver, Canada. Founded by machine learning researchers from MIT, Caltech, Google Research, Microsoft Research, and D-Wave Quantum, its proprietary Enki™ platform uses state-of-the-art generative AI models to design novel, optimized small molecules with improved probability of success for biopharmaceutical partners. variational.ai
View source version on businesswire.com: https://www.businesswire.com/news/home/20260407073931/en/
Website: https://variational.ai/
Contact
Variational AI
Valentin Beuchillot
Senior Manager BD & Marketing
+1 236-818-8624
valentin@variational.ai
This news is a press release provided by Variational AI.
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